Physical Activity May be Best Option for Middle-aged Women Who are Overweight or Obese to Avoid Heart Disease

Avoid heart disease with physical activity, yes, even walking can help.

Physical Activity May be Best Option for Middle-aged Women Who are Overweight or Obese to Avoid Heart Disease That was the conclusion of a study that followed nearly 900 women for seven years. Findings were reported in a paper led by authors at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center, the University Hospital for Einstein, and published in the Journal of Clinical Endocrinology & Metabolism. “Being overweight or obese increases a person’s risk for developing conditions such as hypertension, elevated triglyceride levels and elevated fasting glucose levels‰ÛÓall of them risk factors for heart disease, the leading cause of death in the U.S.,” said lead author Unab Khan, M.B.B.S.,M.S., assistant professor of pediatrics and of family and social medicine at Einstein and attending physician, pediatrics at Montefiore. “With about two out of every three American women overweight or obese, we need to find practical ways to keep them healthier, longer.” The authors identified 866 overweight and obese women, aged 42 to 52 who were enrolled in the Study of Women’s Health Across the Nation, or SWAN, a multicenter, multiethnic study designed to examine the health of women during their middle years. The women studied were categorized as “metabolically benign overweight/obese.” That means they had at most one risk factor for heart disease and therefore were at a lower risk for developing the disease. Throughout the seven-year study, the women were tested annually for heart disease risk factors. They also completed an annual survey describing their physical activity for the prior 12 months, which ranged from active living, caregiving and doing household chores to exercise and sports. During the seven years, 373 of the participants‰ÛÓ43 percent of the total‰ÛÓhad progressed from having at most a single risk factor for heart disease to at-risk overweight/obese, meaning they had developed two or more of the following five heart-disease risk factors: hypertension; low blood level of HDL (“good”) cholesterol; elevated blood levels of triglycerides, elevated fasting glucose level (indicating pre-diabetes or diabetes); and elevated levels of C-reactive protein ( indicating inflammation).

Low-to-moderate physical activity‰ÛÓat the start of the study and during it‰ÛÓwas the only lifestyle factor found to protect overweight/obese women from becoming at-risk for heart disease.

More specifically, women who participated in physical activity during the study were 16 percent less likely to become at-risk for heart disease compared with women who were not physically active.

The researchers also identified several “triggers” that predisposed women to become at-risk for heart disease:

  • Women who had elevated fasting glucose levels or took antidiabetic drugs at the start of the study were more than three times as likely to become at-risk for heart disease compared with women who had normal fasting glucose levels when the study began.
  • Women who had hypertension at the start of the study were three times more likely to fall into the at-risk group compared with women who were not hypertensive at the start of the study.
  • Women who gained weight during the study were 16 percent more likely to become at-risk for heart disease compared with women who did not gain weight.

“A large number of women who began the study‰ÛÓ more than 40 percent of them‰ÛÓ were no longer heart-healthy by the end of it,” said Dr. Khan. “But our study does demonstrate the important role that physical activity can play in protecting overweight or obese women from becoming at-risk for heart disease. Our findings suggest that physical activity may be able to prevent overweight women from developing heart disease even if they have risk factors for the disease.”