Awareness of Memory Loss May Decline 2-3 Years Before Dementia Onset People who will develop dementia may begin to lose awareness of their memory problems two to three years before the actual onset of the disease, according to a new study published in the online issue of Neurologyå¨, the medical journal of the American Academy of Neurology. The study also found that several dementia-related brain changes are associated with the decline in memory awareness. ‰ÛÏOur findings suggest that unawareness of one‰Ûªs memory problems is an inevitable feature of late-life dementia, driven by a buildup of dementia-related changes in the brain,‰Û said study author Robert S. Wilson, PhD, with Rush University Medical Center in Chicago. ‰ÛÏLack of awareness of memory loss is common in dementia, but we haven‰Ûªt known much about how common it is, when it develops or why some people seem more affected than others. Most studies of memory unawareness in dementia have focused on people who have already been diagnosed. In contrast, this new study began following older adults before they showed signs of dementia.‰Û The analysis included 2,092 participants from three ongoing studies that have each followed older adults for more than 10 years. At the beginning of the study, the participants were an average of 76 years old and showed no signs of memory or cognitive impairments. They were given yearly tests of memory and thinking abilities. Participants were also asked how often they had trouble remembering things, and how they would rate their memory compared to 10 years earlier. For the 239 people diagnosed with dementia during the study, memory awareness was stable and then began to drop sharply an average of 2.6 years before the onset of dementia. This followed several years of memory decline. ‰ÛÏAlthough there were individual differences in when the unawareness started and how fast it progressed, virtually everyone had a lack of awareness of their memory problems at some point in the disease,‰Û Wilson said. Unexpectedly, memory unawareness began earlier in younger people than in older people. That may be because older people were more likely to expect memory loss as a normal part of aging, the researchers suggest. The researchers also examined the brains of 385 participants who died during the course of the study, assessing them for seven types of brain changes common to dementia. They found three dementia-related pathologies were associated with the rapid decline in memory awareness: tau proteins or tangles; infarcts, or areas of brain damage; and changes in the protein TDP-43. As those brain changes build up, affected people lose awareness that their memory is failing. ‰ÛÏThis study underscores the importance of family members looking for help from doctors and doctors getting information from friends or family when making decisions about whether a person has dementia, since people may be unable to give reliable reports about the history of their own memory and thinking abilities,‰Û Wilson said.