Drugs That May Cause Memory Loss

The AARP published an interesting article regarding drugs that may cause memory loss. Here is a quick summary. Read the full post.
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Here are 10 of the top offenders.

1. Antianxiety drugs

Examples: Alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), diazepam (Valium), flurazepam (Dalmane), lorazepam (Ativan), midazolam (Versed), quazepam (Doral), temazepam (Restoril) and triazolam (Halcion).

2. Cholesterol-lowering drugs (Statins)

Examples: Atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor) and simvastatin (Zocor).

3. Antiseizure drugs

Examples: Acetazolamide (Diamox), carbamazepine (Tegretol), ezogabine (Potiga), gabapentin (Neurontin), lamotrigine (Lamictal), levetiracetam (Keppra), oxcarbazepine (Trileptal), pregabalin (Lyrica), rufinamide (Banzel), topiramate (Topamax), valproic acid (Depakote) and zonisamide (Zonegran).

4. Antidepressant drugs

Examples: Amitriptyline (Elavil), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil) and trimipramine (Surmontil).

5. Narcotic painkillers

Examples: Fentanyl (Duragesic), hydrocodone (Norco, Vicodin), hydromorphone (Dilaudid, Exalgo), morphine (Astramorph, Avinza) and oxycodone (OxyContin, Percocet). These drugs come in many different forms, including tablets, solutions for injection, transdermal patches and suppositories.

6. Parkinson’s drugs

Examples: Apomorphine (Apokyn), pramipexole (Mirapex) and ropinirole (Requip).


7. Hypertension drugs

Examples: Atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal), sotalol (Betapace), timolol (Timoptic) and some other drugs whose chemical names end with “-olol.”

8. Sleeping aid

Examples: Eszopiclone (Lunesta), zaleplon (Sonata) and zolpidem (Ambien).

9. Incontinence drug

Examples: Darifenacin (Enablex), oxybutynin (Ditropan XL, Gelnique, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol) and trospium (Sanctura).

10. Antihistamines

Examples: Brompheniramine (Dimetane), carbinoxamine (Clistin), chlorpheniramine (Chlor-Trimeton), clemastine (Tavist), diphenhydramine (Benadryl) and hydroxyzine (Vistaril).

I deliberately kept this to the types and brand names so you can spot yours quickly. And when you do it might be worth a conversation with your physician about your medications.åÊ

Is Memory Loss Reversible?

A team of Columbia University Medical Center (CUMC) researchers has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible.åÊ

The hippocampus, a brain region that consists of several interconnected subregions plays a vital role in memory. It was initially thought that age-related memory loss is an early manifestation of Alzheimer’s. These finding offer the strongest causal evidence that age-related memory loss and Alzheimer’s disease are distinct conditions.åÊ

Using live lab mice and eight human brains that were donated for science, the team found that a gene called RbAp48 was linked to the kind of memory loss associated with aging.
The amount of protein the gene produced was almost 50 percent lower in old brains than in younger ones, said the study in the US journal Science Translational Medicine.

They found that switching off the protein in younger mice made them forgetful, while increasing the protein in older mice boosted their memory.

The study was designed to look for more direct evidence that age-related memory loss differs from Alzheimer’s disease.

“The fact that we were able to reverse age-related memory loss in mice is very encouraging,” said lead researcher, Nobel laureate Eric R. Kandel, MD in a release. “But at the very least, it shows that this protein is a major factor, and it speaks to the fact that age-related memory loss is due to a functional change in neurons of some sort. Unlike with Alzheimer’s, there is no significant loss of neurons.”

Source: Science Daily

Another Reason To Take Care of Yourself. There Will be Noone Left To Do It.

The AARP Public Policy Institute released a report called ‰ÛÏThe Aging of the Baby Boom and the Growing Care Gap: A Look at Future Declines in the Availability of Family Caregivers.‰Û

We already know we have a country that is not like Asian cultures that have traditions of caring for family members as they age (though even that is changing). So adding to that fuel is the report‰Ûªs conclusion.
The majority of long-term services and supports are provided by family members. But the supply of family caregivers is unlikely to keep pace with future demand.

  • In 2010, the caregiver support ratio was more than 7 potential caregivers for every person in the high-risk years of 80-plus.
  • By 2030, the ratio is projected to decline sharply to 4 to 1; and it is expected to further fall to less than 3 to 1 in 2050.
  • åÊ
  • 2050 ‰ÛÒ I will be in my 90‰Ûªs hopefully. And my kids will be anywhere from 63 to 73 years old. So the care ain‰Ûªt happening there! So with little unpaid options, what‰Ûªs an elderly bloke to do?
Pay for care. We have written about the cost of that a lot here. Or hey better yet, do everything I can NOW to keep in the best health possible. Of course I use health in the broad sense ‰ÛÒ physical health, emotional health and financial health.

Even if we had enough family caregivers, we do not necessarily have a national culture that embraces our elders so maybe we need to do some work there as well.


The report notes that family caregivers are a key factor in the ability to remain in one‰Ûªs home and in the community when disability strikes. And it says more than two- thirds (68 percent) of Americans believe that they will be able to rely on their families to meet their LTSS needs when they require help. My fellow boomers are in for a rude awakening.

That may not happen so another option here is start what have been called NORC‰Ûªs ‰ÛÒ Naturally Occurring Retirement Communities, where an elder population congregates to live in residential areas and the services they need start to spring up around them. Plus they have each other to lean on as well.

Of course, if you have to pay for care there is little assistance. And if family caregivers go away, there is no way Medicaid can sustain this debacle.


The report notes that the most important predictor of having someone to count on when an individual needs help is being married, because spouses and adult children most often arrange, coordinate, and provide care and social support.


So my advice:

  1. Follow this blogs advice. Age in quality not in crisis and tend to your health ‰ÛÒ physical, financial, emotional.
  2. Foster a dialogue about caring for elders with children and grandchildren. I can already see that my wife and I will have FAR more grandchildren than we had children. Some of that is only natural. Where we have grandparents taking care of their children‰Ûªs children in today‰Ûªs society, well, we need to reverse that.
  3. Think of how you will age in place and in what place. As mentioned, naturally occurring communities offer support.
  4. Get married and stay married!

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